Research Articles A Novel Method for the formation of C-N Bonds Using Oxime Derivatives | TCI

Many amino compounds show biologically interesting activities and have been synthesized using a variety of synthetic methods. In general, there are several methods widely used to synthesize amines, which include 1) reduction of nitrogen-containing functional groups such as nitro or cyano groups, and 2) nucleophilic amination, by which carbon electrophiles are reacted with nitrogen nucleophiles (Gabriel type Reaction). Moreover, electrophilic amination reactions such as combinations of nitrogen electrophiles and carbon nucleophiles are also known, and both chloroamine and hydroxylamine derivatives have been used as nitrogen electrophiles. However, the latter has almost never been efficiently used as a method of synthesizing amino compounds because it lacks general applicability, but has recently recovered attention as an amination method.